NFL Week 10 is seeing injuries across the NFL landscape, which can make locking in official spread picks more challenging. While we advise waiting on a few games, namely Buffalo and Minnesota, there is still plenty to like in the NFL this weekend.
We've got you covered with betting looks for the Week 10 schedule, especially the big Monday Night Football game between Washington and Philadelphia.
Spread: Philadelphia -11
Total: 44 points
We won't get to see Carson Wentz's return to Philly as he's still out with an injury. The Eagles dominated the Commanders back in Week 3, winning 24-8 and sacking Wentz nine times. A repeat defensive line performance feels likely here back at home, and Philly just keeps on winning.
Betting: Eagles -11
Spread: Tampa Bay -2.5
Total: 44.5 points
We've quickly become a believer in the Seahawks. They're 6-3 ATS and stand alone at the top of the NFC West. This team is clicking on all levels, which cannot be said for the 4-5 Bucs. Tampa Bay is 2-6-1 ATS yet favored here in London. We'll gladly take the points and Seattle.
Betting: Seattle +2.5
Spread: Kansas City -8.5
Total: 51 points
The Chiefs should be able to get out to a big lead and take control of this one. Once that begins, Jacksonville is likely to turn a bit one-dimensional and load up the passing game. Kansas City has allowed the eighth-most passing yards per game and three of the last four QBs to face them have gone over their yardage props. Trevor Lawrence should have the volume to pile up some numbers here.
Betting: Trevor Lawrence over 249.5 passing yards (-115 DK)
Spread: Miami -3.5
Total: 49.5 points
Why is Miami only 3.5-point favorites? Tua Tagovailoa has yet to lose a game this year that he starts and finishes, and this Dolphins offense displays its ferocity on a weekly basis. Cleveland's defense has been one of the NFL's worst this year. We'll gladly look to the Dolphins here.
Betting: Dolphins -3.5
Spread: Tennessee -2.5
Total: 39 points
Denver is 7-1 to the under, while Tennessee is 6-2. Bookmakers see the trends just as we do, with this being the lowest over/under of the weekend. Despite the low total, it's still the right move to go under here. The Broncos especially own the distinct combination of an elite defense and a horrific offense. Their pace of play tends to leak into the opposing teams.
Betting: Under 39 points
Spread: Buffalo -3.5
Total: 43 points
This spread has continued to move more and more to the Vikings' end, as it opened at Bills -8. The reason being is around the uncertainty of Josh Allen's elbow. It's irresponsible for us to suggest a betting angle here when we don't yet know the status of Allen. Keep your eye on this game. We do think either way that the Bills can win this game, but you need to wait. If Allen is ruled out, the spread might flip which would give you a great opportunity to potentially take the Bills at nearly a pick 'em.
Betting: Bills ATS, but wait for Josh Allen news to be confirmed.
Spread: Chicago -2.5
Total: 48.5 points
All of a sudden, Justin Fields and this Bears team is actually fun to watch. What a welcomed sight! Detroit has played a handful of mobile quarterbacks this season, and when they do, QBs tend to hit their rushing yards prop. Fields' yardage line is high, but he's averaging 102 yards per game on the ground over his last four, over this total each time. Keep betting on the youngsters' legs.
Betting: Justin Fields over 57.5 rushing yards (-110 DK)
Spread: New York -4.5
Total: 41 points
The Giants should be able to handle business against Houston. The Texans run defense is horrid, allowing 180.6 yards per game, the most in the NFL. Few teams rely on their running back like New York, with Saquon Barkley taking 20+ carries in three straight games. Fresh off the bye, that usage is sure to continue. Expect a big game from Barkley.
Betting: Saquon Barkley over 94.5 rushing yards (-115 DK)
Spread: New Orleans -1.5
Total: 40 points
We're not impressed with the Saints, and Andy Dalton has struggled as starter. It sounds to us like TJ Watt is returning this weekend, which would be a massive boost for the Pittsburgh defense. By no means are the Steelers a good team, but they can win this game, and we'll take them to do so.
Betting: Steelers moneyline +105
Spread: Las Vegas -4.5
Total: 40.5 points
So, it's Jeff Saturday coaching the Colts on Sunday, his first NFL coaching experience ever. It's hard to know what to expect, but luckily he gets to face one of the NFL's most disappointing teams to face in his debut. Our overall thoughts on this game is that we really don't want to watch it, especially with Jonathan Taylor still dealing with an ankle injury. Indy is 8-1 to the under, the best mark in the league.
Betting: Under 40.5 points
Spread: Dallas -4.5
Total: 43 points
The Packers scraped together only nine points against the Lions, one of the NFL's worst defenses. It would be wise to expect another brutal outing for the Green Bay offense, who has looked out of sorts all season long. The Cowboys are off their bye, 6-2 ATS and own a defense that can shut down this Packers team.
Betting: Cowboys -4.5
Spread: Los Angeles -1.5
Total: 40.5 points
The Rams are a bad team. Matthew Stafford isn't likely to play, leaving backup John Wolford to put together a strong effort behind the league's worst offensive line. We don't like LA's chances. Take the Cardinals.
Betting: Cardinals +1.5
Spread: San Francisco -7
Total: 45 points
The Chargers just seem to be perpetually injured, and it sounds like the Chargers will be without Keenan Allen once again. It's a big spread, but San Francisco is the more complete team and fighting to take control of the NFC West. Expect a big game from Christian McCaffrey against a vulnerable Chargers rushing defense.
Betting: 49ers -7
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